{"id":2983,"date":"2026-02-27T03:41:30","date_gmt":"2026-02-27T03:41:30","guid":{"rendered":"https:\/\/www.besteyehospitals.com\/blog\/acanthamoeba-keratitis-definition-uses-and-clinical-overview\/"},"modified":"2026-02-27T03:41:30","modified_gmt":"2026-02-27T03:41:30","slug":"acanthamoeba-keratitis-definition-uses-and-clinical-overview","status":"publish","type":"post","link":"https:\/\/www.besteyehospitals.com\/blog\/acanthamoeba-keratitis-definition-uses-and-clinical-overview\/","title":{"rendered":"acanthamoeba keratitis: Definition, Uses, and Clinical Overview"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">acanthamoeba keratitis Introduction (What it is)<\/h2>\n\n\n\n<p>acanthamoeba keratitis is an infection of the cornea (the clear front \u201cwindow\u201d of the eye) caused by Acanthamoeba organisms.<br\/>\nIt is discussed in eye care because it can be vision-threatening and can be difficult to diagnose early.<br\/>\nIt is most commonly described in the context of contact lens wear, but it can also occur without contact lenses.<br\/>\nIn clinics and hospitals, the term is used to guide specific diagnostic tests and targeted anti-infective treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Why acanthamoeba keratitis used (Purpose \/ benefits)<\/h2>\n\n\n\n<p>acanthamoeba keratitis is not a treatment or device; it is a clinical diagnosis. The \u201cpurpose\u201d of identifying and using this term in eye care is to accurately label a specific cause of corneal infection so that evaluation and management can be appropriately directed.<\/p>\n\n\n\n<p>Key reasons the diagnosis matters include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Targeted infection control:<\/strong> Acanthamoeba exists in active forms (trophozoites) and hardier forms (cysts). Because cysts can be more resistant to some therapies, clinicians often approach suspected acanthamoeba keratitis differently than routine bacterial conjunctivitis or bacterial keratitis.<\/li>\n<li><strong>Vision preservation:<\/strong> Corneal infections can lead to scarring, irregular astigmatism, and reduced vision. Early recognition can influence outcomes, though results vary by clinician and case.<\/li>\n<li><strong>Avoiding misclassification:<\/strong> Symptoms may resemble other conditions (such as herpes simplex keratitis, bacterial keratitis, or fungal keratitis). Using the correct diagnosis helps clinicians choose appropriate tests and medications.<\/li>\n<li><strong>Risk-factor counseling and prevention discussions:<\/strong> The diagnosis prompts discussions about exposures (especially water exposure with lenses) that can be relevant to recurrence prevention and public health messaging.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Indications (When ophthalmologists or optometrists use it)<\/h2>\n\n\n\n<p>Clinicians typically consider acanthamoeba keratitis in situations such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A <strong>painful red eye<\/strong> with corneal findings that do not match typical bacterial conjunctivitis<\/li>\n<li><strong>Severe eye pain that seems \u201cout of proportion\u201d<\/strong> to early exam findings (a commonly taught clinical clue, though not specific)<\/li>\n<li><strong>Contact lens wear<\/strong>, especially when paired with water exposure (showering, swimming, hot tubs) or poor lens-case hygiene history<\/li>\n<li><strong>Persistent keratitis<\/strong> that responds poorly to initial antibacterial or antiviral therapy<\/li>\n<li>Corneal signs that may include <strong>punctate epithelial defects<\/strong>, <strong>pseudodendrites<\/strong> (branching surface lesions that can mimic herpes), or <strong>stromal infiltrates<\/strong><\/li>\n<li><strong>Perineural infiltrates<\/strong> (inflammation tracking along corneal nerves), sometimes described as radial keratoneuritis<\/li>\n<li>A <strong>ring-shaped stromal infiltrate<\/strong> later in the disease course (not present in all cases)<\/li>\n<li>Corneal infection following <strong>corneal trauma<\/strong> with exposure to soil, dust, or contaminated water<\/li>\n<li>Suspicion of mixed infection (coinfection can occur; the workup may broaden accordingly)<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Contraindications \/ when it\u2019s NOT ideal<\/h2>\n\n\n\n<p>Because acanthamoeba keratitis is a diagnosis rather than a procedure, \u201ccontraindications\u201d mainly apply to (1) when the diagnosis is less likely or (2) when certain diagnostic or therapeutic approaches may not be ideal.<\/p>\n\n\n\n<p>Situations where labeling a case as acanthamoeba keratitis may be less fitting, or where other approaches may be prioritized, include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Clinical presentations more typical of <strong>non-infectious<\/strong> corneal conditions (for example, dry eye\u2013related superficial keratopathy), where the primary workup may focus on ocular surface disease<\/li>\n<li>Stronger evidence for <strong>alternative infectious causes<\/strong>, such as classic bacterial corneal ulcer patterns, classic fungal features (varies by region and case), or classic herpes simplex keratitis findings<\/li>\n<li><strong>Contraindications to invasive sampling<\/strong> (case-dependent), such as extreme corneal thinning where scraping or biopsy could increase risk; clinicians may emphasize non-invasive testing when feasible<\/li>\n<li><strong>Limited access to confirmatory testing<\/strong> (for example, confocal microscopy or PCR may not be available in some settings), requiring a broader differential diagnosis and stepwise reassessment<\/li>\n<li>Use of medications that can affect infection behavior (for example, <strong>topical corticosteroids<\/strong>) may be approached cautiously and varies by clinician and case, particularly early in suspected infection<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How it works (Mechanism \/ physiology)<\/h2>\n\n\n\n<p>acanthamoeba keratitis develops when Acanthamoeba organisms come into contact with the corneal surface and are able to adhere, invade, and trigger inflammation.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Mechanism at a high level<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Exposure and adhesion:<\/strong> Acanthamoeba is commonly found in the environment, including water and soil. The organism can attach to the corneal epithelium (the cornea\u2019s outer layer), especially when the surface is disrupted.<\/li>\n<li><strong>Microtrauma and barrier breakdown:<\/strong> Contact lens wear can create micro-abrasions and alter the tear film and oxygen environment, potentially making it easier for organisms to enter. This is a risk context, not a guarantee.<\/li>\n<li><strong>Trophozoites and cysts:<\/strong> Acanthamoeba has an active feeding form (trophozoite) and a more resilient dormant form (cyst). Cysts can contribute to persistence and relapse risk, and they help explain why treatment courses may be prolonged.<\/li>\n<li><strong>Inflammation and nerve involvement:<\/strong> The cornea is highly innervated. Inflammation may involve corneal nerves (keratoneuritis), contributing to notable pain.<\/li>\n<li><strong>Stromal disease and scarring:<\/strong> If deeper layers (the corneal stroma) are involved, inflammatory damage can lead to haze, scarring, thinning, and irregular corneal shape that affects vision.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Relevant eye anatomy<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Corneal epithelium:<\/strong> First barrier; early disease may be more surface-based.<\/li>\n<li><strong>Corneal stroma:<\/strong> The thick, transparent middle layer; deeper involvement is associated with more visual impact and longer recovery.<\/li>\n<li><strong>Corneal nerves:<\/strong> Dense sensory nerves help explain why keratitis can be painful and light-sensitive.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Onset, duration, reversibility<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Onset:<\/strong> Can be subacute, with symptoms evolving over days to weeks; presentation varies.<\/li>\n<li><strong>Duration:<\/strong> Often prolonged compared with many bacterial infections, especially if diagnosis is delayed or cysts persist.<\/li>\n<li><strong>Reversibility:<\/strong> Infection control is possible, but residual scarring or irregular astigmatism can remain. Visual recovery varies by clinician and case.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">acanthamoeba keratitis Procedure overview (How it\u2019s applied)<\/h2>\n\n\n\n<p>acanthamoeba keratitis is not a single procedure. In practice, it is \u201capplied\u201d as a structured clinical workflow: evaluating risk, examining the cornea, confirming the organism when possible, then monitoring response over time.<\/p>\n\n\n\n<p>A typical high-level sequence may include:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\n<p><strong>Evaluation \/ exam<\/strong>\n   &#8211; Symptom review (pain, redness, tearing, light sensitivity, blurred vision)\n   &#8211; Risk-factor history (contact lens type and routine, water exposure, recent eye trauma)\n   &#8211; Slit-lamp examination with fluorescein staining to assess epithelial defects and corneal involvement<\/p>\n<\/li>\n<li>\n<p><strong>Preparation<\/strong>\n   &#8211; Planning diagnostic approach based on severity and available tools\n   &#8211; Removing contact lenses if present and considering lens\/case evaluation in some protocols (practice varies)<\/p>\n<\/li>\n<li>\n<p><strong>Intervention \/ testing<\/strong>\n   &#8211; <strong>Corneal sampling<\/strong> (for example, corneal scraping) for microscopy and culture in selected cases\n   &#8211; <strong>PCR testing<\/strong> on corneal samples where available\n   &#8211; <strong>In vivo confocal microscopy<\/strong> (a specialized imaging test) may be used in some centers to visualize features consistent with Acanthamoeba\n   &#8211; Broader testing if bacterial, fungal, or viral causes remain in the differential diagnosis<\/p>\n<\/li>\n<li>\n<p><strong>Immediate checks<\/strong>\n   &#8211; Reassessment of corneal integrity (epithelial status, thinning risk)\n   &#8211; Baseline documentation (photos, drawings, measurements) to compare over time<\/p>\n<\/li>\n<li>\n<p><strong>Follow-up<\/strong>\n   &#8211; Close monitoring of symptoms and corneal signs to judge response and detect complications\n   &#8211; Adjusting the plan based on response, tolerance, and evolving diagnosis (varies by clinician and case)<\/p>\n<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\">Types \/ variations<\/h2>\n\n\n\n<p>acanthamoeba keratitis can be described in several clinically useful ways. These \u201ctypes\u201d are not always separate categories, but they help students and clinicians communicate severity and expected course.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">By depth and stage<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Epithelial (superficial) involvement:<\/strong> Early disease may be concentrated in the surface layer with punctate epithelial changes.<\/li>\n<li><strong>Stromal keratitis:<\/strong> Deeper infiltration and inflammation within the stroma; may be associated with greater risk of scarring and longer recovery.<\/li>\n<li><strong>Advanced disease:<\/strong> Can include ring infiltrate, thinning, persistent epithelial defects, or spread beyond the cornea (less common, case-dependent).<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">By key clinical features<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Keratoneuritis pattern:<\/strong> Inflammation tracking along corneal nerves (a recognized clinical description).<\/li>\n<li><strong>Ring infiltrate pattern:<\/strong> A circular stromal infiltrate that may appear later and is not exclusive to this infection.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">By context and risk factors<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Contact lens\u2013associated acanthamoeba keratitis:<\/strong> The most commonly discussed setting in many teaching materials.<\/li>\n<li><strong>Non\u2013contact lens\u2013associated cases:<\/strong> May involve trauma, environmental exposure, or other ocular surface vulnerabilities.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">By diagnostic approach (practical variation)<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Clinically suspected cases:<\/strong> Diagnosis is based on history and exam findings when confirmatory tests are pending or unavailable.<\/li>\n<li><strong>Laboratory- or imaging-supported cases:<\/strong> Confirmation via culture, PCR, microscopy, or confocal microscopy (availability varies by facility).<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pros and cons<\/h2>\n\n\n\n<p>These points reflect practical advantages and limitations of modern recognition and management pathways for acanthamoeba keratitis, not \u201cpros and cons\u201d of getting the condition.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Pros<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Can be <strong>recognized based on risk factors and characteristic patterns<\/strong>, prompting targeted workup<\/li>\n<li>Specialized testing (PCR, confocal microscopy) can <strong>support diagnosis<\/strong> in some settings<\/li>\n<li>Medical therapy can <strong>control infection in many cases<\/strong>, though timelines vary<\/li>\n<li>Structured follow-up allows clinicians to <strong>monitor for progression, scarring, or complications<\/strong><\/li>\n<li>Increased awareness has improved earlier consideration in contact lens\u2013related keratitis<\/li>\n<li>Diagnosis can guide <strong>prevention counseling<\/strong> and safer lens-handling discussions<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Cons<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Early findings can <strong>mimic other keratitis types<\/strong>, delaying correct diagnosis<\/li>\n<li>Treatment courses can be <strong>prolonged<\/strong> and require frequent reassessment (varies by case)<\/li>\n<li>Some topical therapies can cause <strong>ocular surface irritation or toxicity<\/strong>, affecting comfort and adherence (varies by medication and patient)<\/li>\n<li>Visual outcomes may be limited by <strong>residual scarring or irregular astigmatism<\/strong><\/li>\n<li>Confirmatory testing may be <strong>unavailable<\/strong> in some clinics or regions<\/li>\n<li>Severe cases may still require <strong>surgical management<\/strong> for scarring or structural complications (case-dependent)<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Aftercare &amp; longevity<\/h2>\n\n\n\n<p>Aftercare for acanthamoeba keratitis is primarily about <strong>monitoring and supporting the ocular surface over time<\/strong>. Because disease course and response vary widely, clinicians usually individualize follow-up intervals, tests, and medication adjustments.<\/p>\n\n\n\n<p>Factors that can influence longer-term outcomes include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Severity at presentation:<\/strong> Superficial disease generally has more favorable potential than deep stromal disease, but outcomes vary.<\/li>\n<li><strong>Time to accurate diagnosis:<\/strong> Earlier targeted therapy may reduce progression in some cases, though it is not a guarantee.<\/li>\n<li><strong>Adherence and tolerance:<\/strong> Treatment regimens can be demanding. Irritation or surface toxicity can affect consistency (varies by medication and patient).<\/li>\n<li><strong>Ocular surface health:<\/strong> Dry eye, blepharitis, epithelial instability, and contact lens\u2013related surface changes can influence healing.<\/li>\n<li><strong>Coexisting infection or inflammation:<\/strong> Coinfection or significant inflammation may complicate the course (case-dependent).<\/li>\n<li><strong>Corneal remodeling after infection:<\/strong> Even after organism control, scarring and irregular curvature can affect vision quality and may require optical rehabilitation planning (for example, glasses, specialty contact lenses, or other options depending on the eye).<\/li>\n<\/ul>\n\n\n\n<p>\u201cLongevity\u201d in this context usually refers to how long symptoms and corneal changes persist. Some people improve over weeks, while others have a longer course with months of monitoring, depending on depth of involvement, organism burden, and treatment response.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Alternatives \/ comparisons<\/h2>\n\n\n\n<p>Because acanthamoeba keratitis is a specific infection, \u201calternatives\u201d generally mean <strong>other diagnoses<\/strong> (what else it could be) and <strong>other management pathways<\/strong> used for those conditions.<\/p>\n\n\n\n<p>Common comparisons include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Bacterial keratitis vs acanthamoeba keratitis<\/strong><\/li>\n<li>Bacterial ulcers often have a more acute course and may respond quickly to appropriate antibacterial therapy.<\/li>\n<li>\n<p>acanthamoeba keratitis may have a more indolent course and can require different anti-infective agents aimed at both trophozoites and cysts.<\/p>\n<\/li>\n<li>\n<p><strong>Fungal keratitis vs acanthamoeba keratitis<\/strong><\/p>\n<\/li>\n<li>Both can be associated with environmental exposure and can be challenging to treat.<\/li>\n<li>\n<p>Diagnostic confirmation often relies on microscopy\/culture\/PCR, and response timelines can be longer than typical bacterial infections.<\/p>\n<\/li>\n<li>\n<p><strong>Herpes simplex keratitis vs acanthamoeba keratitis<\/strong><\/p>\n<\/li>\n<li>Herpes can cause dendritic lesions and decreased corneal sensation; acanthamoeba keratitis can mimic some epithelial patterns but often has notable pain and may show perineural inflammation.<\/li>\n<li>\n<p>Treatments differ substantially, so distinguishing them is clinically important.<\/p>\n<\/li>\n<li>\n<p><strong>Non-infectious keratitis (dry eye, exposure, toxic\/medicamentosa) vs acanthamoeba keratitis<\/strong><\/p>\n<\/li>\n<li>Non-infectious conditions are typically managed by addressing surface inflammation and tear film issues rather than anti-infective therapy.<\/li>\n<li>\n<p>Persistent pain, focal infiltrates, and risk factors may shift suspicion toward infection and prompt additional testing.<\/p>\n<\/li>\n<li>\n<p><strong>Medication-based management vs surgical approaches<\/strong><\/p>\n<\/li>\n<li>Medical therapy is central to infection control in many cases.<\/li>\n<li>Surgery (such as corneal transplantation) may be considered for structural complications or visually significant scarring in selected cases; timing and approach vary by clinician and case.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">acanthamoeba keratitis Common questions (FAQ)<\/h2>\n\n\n\n<p><strong>Q: Is acanthamoeba keratitis contagious from person to person?<\/strong><br\/>\nacanthamoeba keratitis is generally understood as an environmental infection rather than a person-to-person contagious disease. It is associated with exposure pathways (often involving contact lens practices and water exposure). Clinicians still use standard hygiene precautions in clinical settings.<\/p>\n\n\n\n<p><strong>Q: Why does acanthamoeba keratitis hurt so much?<\/strong><br\/>\nThe cornea has many sensory nerves. Inflammation can involve these nerves (sometimes described as keratoneuritis), which can contribute to significant pain and light sensitivity. Pain levels vary by individual and by stage of disease.<\/p>\n\n\n\n<p><strong>Q: How is acanthamoeba keratitis diagnosed?<\/strong><br\/>\nDiagnosis typically starts with history and slit-lamp examination. Confirmation may involve corneal scraping for microscopy\/culture, PCR testing, or in vivo confocal microscopy, depending on availability and clinician preference. Sometimes the diagnosis remains \u201csuspected\u201d until treatment response and test results clarify the cause.<\/p>\n\n\n\n<p><strong>Q: How long does acanthamoeba keratitis last?<\/strong><br\/>\nThe course can be longer than many other corneal infections, particularly when cyst forms are involved. Some cases improve over weeks, while others require months of monitoring and therapy adjustments. Duration depends on severity, timing of diagnosis, and response to treatment.<\/p>\n\n\n\n<p><strong>Q: Can acanthamoeba keratitis cause permanent vision loss?<\/strong><br\/>\nIt can lead to lasting corneal scarring, irregular astigmatism, or other changes that affect vision quality. Some people recover useful vision, while others may have persistent deficits. Outcomes vary by clinician and case, including the depth of corneal involvement and complications.<\/p>\n\n\n\n<p><strong>Q: What does treatment usually involve?<\/strong><br\/>\nManagement often includes topical anti-infective medications specifically selected for Acanthamoeba, sometimes combined with other therapies depending on inflammation and coinfection concerns. Regimens can be intensive and require close follow-up to monitor healing and medication tolerance. Exact medications and schedules vary by clinician and case.<\/p>\n\n\n\n<p><strong>Q: Will I need surgery if I have acanthamoeba keratitis?<\/strong><br\/>\nMany cases are managed medically, especially when recognized earlier. Surgery may be considered for complications like severe scarring, corneal thinning, or structural problems, or when vision remains significantly affected after infection control. Decisions depend on corneal status and overall risk-benefit assessment.<\/p>\n\n\n\n<p><strong>Q: Can I drive or use screens during recovery?<\/strong><br\/>\nDriving and screen tolerance depend on pain, light sensitivity, and visual clarity. Many people experience fluctuating vision during active keratitis and healing. Safety decisions are individualized and often discussed during follow-up visits.<\/p>\n\n\n\n<p><strong>Q: How much does evaluation and treatment cost?<\/strong><br\/>\nCosts vary widely by region, insurance coverage, testing availability (such as PCR or confocal microscopy), medication selection, and the number of follow-up visits. More severe or prolonged cases can increase overall cost. Clinics may provide general cost counseling based on local systems.<\/p>\n\n\n\n<p><strong>Q: Can I wear contact lenses again after acanthamoeba keratitis?<\/strong><br\/>\nWhether contact lenses are appropriate later depends on corneal healing, scarring, dryness, and clinician assessment of risk factors. Some individuals return to lenses (sometimes specialty lenses), while others rely on glasses or consider other vision-correction options. The safest path is case-specific and based on corneal stability over time.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>acanthamoeba keratitis is an infection of the cornea (the clear front \u201cwindow\u201d of the eye) caused by Acanthamoeba organisms. It is discussed in eye care because it can be vision-threatening and can be difficult to diagnose early. It is most commonly described in the context of contact lens wear, but it can also occur without contact lenses. In clinics and hospitals, the term is used to guide specific diagnostic tests and targeted anti-infective treatment.<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-2983","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>acanthamoeba keratitis: Definition, Uses, and Clinical Overview - Best Eye Hospitals<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.besteyehospitals.com\/blog\/acanthamoeba-keratitis-definition-uses-and-clinical-overview\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"acanthamoeba keratitis: Definition, Uses, and Clinical Overview - Best Eye Hospitals\" \/>\n<meta property=\"og:description\" content=\"acanthamoeba keratitis is an infection of the cornea (the clear front \u201cwindow\u201d of the eye) caused by Acanthamoeba organisms. It is discussed in eye care because it can be vision-threatening and can be difficult to diagnose early. It is most commonly described in the context of contact lens wear, but it can also occur without contact lenses. 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